KAP1 regulates gene networks controlling T‐cell development and responsiveness
نویسندگان
چکیده
منابع مشابه
KAP1 regulates gene networks controlling mouse B-lymphoid cell differentiation and function.
Chromatin remodeling is fundamental for B-cell differentiation. In the present study, we explored the role of KAP1, the cofactor of KRAB-ZFP transcriptional repressors, in this process. B-lymphoid-specific Kap1-KO mice displayed reduced numbers of mature B cells, lower steady-state levels of Abs, and accelerated rates of decay of neutralizing Abs after viral immunization. Transcriptome analyses...
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Australian Research Council Centre of Excellence for Integrative Legume Research, The University of Queensland, St Lucia, Brisbane, 4072 Australia (C.A.B.); School of Plant Science, University of Tasmania, G.P.O. Box 252–55 Hobart, Tasmania 7001 Australia (J.L.W.); Department of Biology, Carleton College, Northfield, Minnesota 55057 (S.R.S.); and Department of Crop Genetics, John Innes Centre, ...
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ژورنال
عنوان ژورنال: The FASEB Journal
سال: 2012
ISSN: 0892-6638,1530-6860
DOI: 10.1096/fj.12-206177